Contrary to the belief that DNA is the same in every tissue of an individual's body, researchers at the Indiana University School of Medicine have recently discovered that it may, in fact, have variations. Last month, in The Scientist, findings of this study were reported. The research team at McGill was searching for genes believed to cause a fatal condition called abdominal aortic aneurysm (AAA). They found that DNA extracted from diseased abdominal aortic tissue did not exactly match genomic DNA taken from blood leukocytes of the same individual. Endocrinologist, Morris Schweitzer, who led the study, said "We did not expect to find a difference in the tissue [genes] compared to the leukocyte [genes]."

This study's findings are raising questions as to the reliability of many current studies on systemic diseases. For instance, tests for diabetes and atherosclerosis are typically based only on DNA extracted from blood samples. This new study suggests that relying solely on DNA from blood may not reveal serious, potentially fatal medical conditions.

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