Maternal Serum Screening

Maternal Serum Screening

Maternal Serum Screening involves looking for specific proteins and hormones in an expectant mother's blood. Maternal Serum Screening is arranged by your health care provider and uses blood taken at 15 to 20 weeks of pregnancy. It is used to screen for Down syndrome and Trisomy 18 for women who have NOT had first trimester screening or integrated prenatal screening.

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First ScreenTM
First Screen is performed between the 10th and the 13th week of gestation. Measurements of the maternal serum markers pregnancy associated plasma protein (PAPP-A) and human chorionic gonadotropin (hCG) are combined with an NT ultrasound measurement to estimate the fetal risk for Down syndrome or trisomy 18. First Screen detects approximately 83% of Down syndrome pregnancies and 80% of trisomy 18 pregnancies.
Integrated Screen TM
Integrated Screen TM
Integrated Screen combines the results of screening performed in the first and second trimesters with an NT ultrasound measurement into one risk assessment. In the first trimester, between the 10th and the 13th week of gestation, PAPP-A is measured in a maternal blood sample and an NT ultrasound measurement is obtained. In the second trimester, a maternal blood sample taken between the 15th and the 21st week of gestation is analyzed for alphafetoprotein (AFP), unconjugated estriol (uE3), hCG and dimeric Inhibin-A.
Serum Integrated Screen TM
Serum Integrated Screen TM
Serum Integrated Screen combines results of screenings performed in the first and second trimester into one risk assessment, but does not use an NT ultrasound measurement. In the first trimester, between the 10th and the 13th week of gestation, PAPP-A is measured in a maternal blood sample. In the second trimester, a maternal blood sample is taken between the 15th and the 21st week of gestation. The maternal serum markers AFP, hCG, uE3 and dimeric Inhibit-A are measured.
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