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| Why a DNA Test Result Might Be
Inconclusive? |
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The DNA Identity Testing Center of
Bio-Synthesis, Inc. is an active member of the AABB Relationship
Testing Accreditation Program and actively participates in
proficiency testing by the College of American Pathologists.
With nearly 15 years experience in the DNA testing field, law
enforcement, legal representatives and individuals alike trust
BSI with their private and legal DNA testing issues, worldwide. |
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Inconclusive
Test Result
DNA test will provide a conclusive result, whether
it confirms a biological relationship or
identifies an unknown sample. Sometimes, however,
an inconclusive result may be obtained. some
samples may not yield sufficient DNA profiles,
which would mean that there would be a lack of
sufficient data for use in calculating a
conclusive result. Insufficient data may tend to
come from non-standard or forensic evidence
samples, which may be old or degraded. Time and
storage conditions can greatly affect the
viability of DNA samples. Usually, new samples
must be obtained, if available, in order to
determine a conclusive result or, perhaps, other,
more sensitive testing methods may be utilized. |
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Parentage Test
In a parentage test, specifically one between an
alleged parent and child only, a mutation can
sometimes be found. Mutations are differences in
alleles, which usually vary by one unit, i.e.
alleged parent has a 10 allele and the child has
an 11 allele. Known mutations have a specific
frequency in any given racial population. When
that frequency is figured into the Probability of
Parentage, it will lower that percentage and
sometimes can cause it to fall below 99%. In this
instance, it would be recommended to have the
other, known parent provide a sample, or if that
is not possible, perform extended testing to see
if the Probability of Parentage increases. |
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Relationship Tests
In other relationship tests, like those between
siblings or grandparents and grandchildren, the
Probability of Relationship may fall into an
inconclusive range. This is because these
individuals have a second degree relationship and
will likely share fewer similarities in their DNA
profiles than would a parent and child (first
degree relationship). If, for example, a
siblingship test resulted in a 70% Probability of
Relationship, it would be considered "uncertain"
that the individuals would be related as such. If
the individuals were, in fact, biological
siblings, testing of their parent(s) would result
in an increased Probability of Relationship,
thereby confirming the fact that they were
siblings. Extended testing of additional markers
might also be an option for increasing Probability
of Relationship in a situation like this. |
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